Chiefs vs Eagles Match Preview

The standout game from Week Two of the 2025 NFL season comes from Arrowhead Stadium on Sunday as the Kansas City Chiefs face the Philadelphia Eagles in a Super Bowl rematch, which will be televised on both Sky Sports NFL and Channel 5 Action at 9:25pm BST.

The Eagles began their Super Bowl defence with a battling 24-20 win over the Cowboys, and having dominated Kansas City 40-22 in February’s Lombardi Trophy decider, will attempt to move to 2-0 at the expense of Patrick Mahomes and the Chiefs on Sunday.

The home team, meanwhile, are bidding for a first win of the season following a 27-21 Week One loss to divisional rivals the LA Chargers in Brazil. Other key match-ups on Sunday include the AFC East clash between the New England Patriots and a beleaguered Miami Dolphins team, while the Atlanta Falcons and Minnesota Vikings meet in the late game. 

Week Two NFL schedule (all times BST)

Thursday

• Commanders @ Packers, 1.15am (early Friday)

Sunday

• Rams @ Titans, 6pm
• Seahawks @ Steelers, 6pm
• Bills @ Jets, 6pm 
• Bears @ Lions, 6pm 
• Giants @ Cowboys, 6pm 
• Browns @ Ravens, 6pm 
• 49ers @ Saints, 6pm 
• Patriots @ Dolphins, 6pm 
• Jaguars @ Bengals, 6pm 
• Panthers @ Cardinals, 9.05pm 
• Broncos @ Colts, 9.05pm 
• Eagles @ Chiefs, 21.25pm
• Falcons @ Vikings, 1.20am (early Monday)

Monday

• Buccaneers @ Texans, 12am (early Tuesday)
• Chargers @ Raiders, 3am (early Tuesday)

Chiefs vs Eagles Betting Tips

Tip 1: Eagles to win @ 20/23 with bet365

For the first time since a Week Six clash with Buffalo in 2022, the Chiefs find themselves as home underdogs in a game in which Mahomes has been the starting quarterback. On that occasion, a late Bills touchdown sealed the win for the road team, and the result could be the same against a Chiefs team lacking offensive firepower in the likely absence of receiver Xavier Worthy, who left the field early against the Chargers after a clash with Travis Kelce.

The Eagles have the ability to score heavily against the Chiefs – something they demonstrated in spectacular fashion in the Super Bowl – and it’s hard to see Andy Reid’s banged up offence being able to keep up, even if Mahomes conjures some magic. The spread is set at 1 in favour of the Eagles, so it makes sense to keep it simple and take them on the money line.

Tip 2: Saquon Barkley over 2.5 receptions @ 13/10 with bet365

The Chiefs did a good job of stopping Saquon Barkley on the ground in the Super Bowl, but the Eagles’ superstar running back was a regular target for Jalen Hurts in the air on that occasion, claiming a season-high six catches from seven targets. Barkley was frequently targeted in the passing game against the Cowboys in Week One, hauling in four catches, and he could be heavily involved again at Arrowhead.

Tip 3: Marquise Brown first touchdown scorer @ 10/1 with bet365

Marquise ‘Hollywood’ Brown proved to be the main beneficiary following Worthy’s departure last week as he was targeted 16 times by Mahomes, hauling in 10 catches for 99 total yards. The seventh-year wide receiver did little in an interrupted first season in Kansas City last year, but he could be involved early and often with Mahomes’ passing options thin on the ground. Hollywood is worth looking at in all reception markets, but perhaps the best value lies with backing him to score the first touchdown at double-digit odds.